Patient compliance with treatment regimens is a well established challenge in chronic disease, with diabetes, asthma and hypertension having the worse patient compliance track records.
One of the largest Pharmacy Benefit Managers, Express Scripts, will be more actively monitoring patients for compliance and contacting if they fall behind in their treatment. http://www.stltoday.com/business/local/express-scripts-to-spot-pill-skippers-with-new-program/article_8b90b844-87ea-11e1-ab90-0019bb30f31a.html
What is interesting is that they will be packaging and selling to employers as a service offering.
And it only benefits Express scripts to encourage refills.